TY  - THES
T1  - Genomic selection in synthetic populations
A1  - Müller,Dominik
Y1  - 2019/01/28
N2  - The foundation of genomic selection has been laid at the beginning of this century. Since then, it has developed into a very active field of research. Although it has originally been developed in dairy cattle breeding, it rapidly attracted the attention of the plant breeding community and has, by now (2017), developed into an integral component of the breeding armamentarium of international companies. Despite its practical success, there are numerous open questions that are highly important to plant breeders. The recent development of large-scale and cost-efficient genotyping platforms was the prerequisite for the rise of genomic selection. Its functional principle is based on information shared between individuals. Genetic similarities between individuals are assessed by the use of genomic fingerprints. These similarities provide information beyond mere family relationships and allow for pooling information from phenotypic data. In practice, first a training set of phenotyped individuals has to be established and is then used to calibrate a statistical model. The model is then used to derive predictions of the genomic values for individuals lacking phenotypic information. Using these predictions can save time by accelerating the breeding program and cost by reducing resources spent for phenotyping. A large body of literature has been devoted to investigate the accuracy of genomic selection for unphenotyped individuals. However, training individuals are themselves often times selection candidates in plant breeding, and there is no conceptual obstacle to apply genomic selection to them, making use of information obtained via marker-based similarities. It is therefore also highly important to assess prediction accuracy and possibilities for its improvement in the training set. Our results demonstrated that it is possible to increase accuracy in the training set by shrinkage estimation of marker-based relationships to reduce the associated noise. The success of this approach depends on the marker density and the population structure. The potential is largest for broad-based populations and under a low marker density. Synthetic populations are produced by intermating a small number of parental components, and they have played an important role in the history of plant breeding for improving germplasm pools through recurrent selection as well as for actual varieties and research on quantitative genetics. The properties of genomic selection have so far not been assessed in synthetics. Moreover, synthetics are an ideal population type to assess the relative importance of three factors by which markers provide information about the state of alleles at QTL, namely (i) pedigree relationships, (ii) co-segregation and (ii) LD in the source germplasm. Our results show that the number of parents is a crucial factor for prediction accuracy. For a very small number of parents, prediction accuracy in a single cycle is highest and mainly determined by co-segregation between markers and QTL, whereas prediction accuracy is reduced for a larger number of parents, where the main source of information is LD within the source germplasm of the parents. Across multiple selection cycles, information from pedigree relationships rapidly vanishes, while co-segregation and ancestral LD are a stable source of information. Long-term genetic gain of genomic selection in synthetics is relatively unaffected by the number of parents, because information from co-segregation and from ancestral LD compensate for each other. Altogether, our results provide an important contribution to a better understanding of the factors underlying genomic selection, and in which cases it works and what information contributes to prediction accuracy.
KW  - Genom
KW  - Auslese
KW  - Population
KW  - Prognose
CY  - Hohenheim
PB  - Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim
AD  - Garbenstr. 15, 70593 Stuttgart
UR  - http://opus.uni-hohenheim.de/volltexte/2019/1565
ER  -